> Lipophile Modifikationen
Distearoyl Lipid (5' modification)

Distearoyl lipid-oligonucleotide conjugates consist of a negatively charged DNA and two diamine-linked long hydrocarbon chains (stearic acid). They are thus relatively similar to a natural phospholipid structure and can form micelles. Distearoyl lipids facilitate cell permeability or anchoring of oligonucleotides on the cell surface.
A distearoyl lipid phosphoramidite enables the synthesis of oligonucleotides with the corresponding 5´-modification.

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Distearoyl Lipid 5' modification: 5´-Distearoyl Lipid
5´-Distearoyl Lipid