smiFISH - OligoPool for in situ RNA detection
smiFISH - single molecule inexpensive fluorescence in situ hybridisation

A set consisting of short, target-binding, unlabelled oligo probes (OligoPool) and a double-labelled secondary probe allows extremely sensitive and specific in situ RNA detection.



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YOUR TRUSTED PARTNER FOR OLIGONUCLEOTIDES:
FAST, COMPETENT, AND RELIABLE!
Take advantage of state-of-the-art synthesis technology:
Oligonucleotides with all popular modifications at reasonable prices and with a reliable quality. Oligos for PCR, short, unmodified and quickly delivered are offered as well as high quality RNA oligos, probes for qPCR and FISH or reliable cloning oligos of (nearly) any length.
Talking about oligonucleotides:
talk to biomers.net!
Duplex Stability
In order to increase the affinity and stability of a duplex DNA, there is a range of different modified bases to improve hybridisation:

- Minor Groove Binder (MGB) and LNA
- C-5 Propynyl-Pyrimidines (pdC, pdU)
- Aminoethyl-phenoxazine-deoxycytidine (AP-dC, (G-clamp))
- 5-Methyl-deoxycytidine (5-Me-dC)
- 2-Amino-deoxyadenosine (2-Amino-dA)
Mediator Probe PCR (MP PCR)
The new real-time PCR application is characterised by

- a high sensitivity,
- tremendous specificity and a
- high degree of flexibility
Electrochemical detection
Oligonucleotide-based biosensors (E-sensors) for electrochemical detection can be labelled with

- Methylene blue
- Ferrocene or
- Anthraquinone
- Viologen


Early Bird Discount
Between 6:00 and 9:30 am you‘ll get a special discount of
5 % on all your orders
!
Literature Highlights
Protocols, interesting literature and further information around the topic of oligonucleotides.

- Smart-Seq for transkriptome analysis (Picelli et al., 2014)
- Mediator Probe PCR (Faltin et al., 2012)
- MiL-FISH: Multi-labelled oligonucleotides (Schimak et al., 2015)
DNA oligos
- Unmodified oligos
- short and extra long oligos
- XXL DNA (10-500 mg)
- Sequence modifications
- Wobbles
RNA oligos
- unmodified RNA
up to 120 bases

- RNA oligo annealing
- XL and XXL RNA (5-50 mg)
- RNA modifications
- 2´-modified RNA
qPCR Probes
- Dual-Labelled Oligos
- Double Quenched Probes
- MGB Probes
- Molecular Beacons
- Scorpions
- FRET Probes
PNA oligos
- Peptide nucleic acid oligomers (PNA)
- 6-25 bases
- various modifications possible
- extreme stability
FISH Probes
- Fluorescence probes
mono-, dope-, tetraProbes
- multiProbes
- HRP probes
- smiFISH OligoPools
XXXL qPCR Probes
Do you need even more?
qPCR probes are also possible in extra large XXL scales
- HPLC purification and
Maldi-MS are included
Just contact us!