License for click chemistry
biomers.net has acquired an extensive global license from baseclick to perform azide-alkyne click reactions on nucleic acids. This license includes the synthesis of modified oligos by copper-catalysed click chemistry, as well as the allocation of clickable oligos, followed by realisation of click reactions for research purposes only. In particular, the technology protected by baseclick for internal click modification of nucleic acids on heterocyclic bases (via 5-alkyne pyrimidines) is also included in the agreement. biomers.net offers now the entire portfolio of click-modified oligos worldwide.
YOUR TRUSTED PARTNER FOR OLIGONUCLEOTIDES:
FAST, COMPETENT, AND RELIABLE!
Take advantage of state-of-the-art synthesis technology:
Oligonucleotides with all popular modifications at reasonable prices and with a reliable quality. Oligos for PCR, short, unmodified and quickly delivered are offered as well as high quality RNA oligos, probes for qPCR and FISH or reliable cloning oligos of (nearly) any length.
Talking about oligonucleotides:
talk to biomers.net!
Photoreactive linkers
Photoreactive linkers for specific release of a molecule or the coupling of two biomolecules at particular time via irradiation with light (UV light):

-Photocleavable linkers
-Photocross linkers

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Antisense oligos with 2´-O-MOE modification
- increased stability to enzymatic degradation
- improved distribution in cell
- bind with greater affinity to complementary RNA

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Duplex stability
In order to increase the affinity and stability of a duplex DNA, there is a range of different modified bases to improve hybridisation:

- Minor Groove Binder (MGB)
- C-5 Propynyl-Pyrimidines (pdC, pdU)
- Aminoethyl-phenoxazine-deoxycytidine (AP-dC, (G-clamp))
- 5-Methyl-deoxycytidine (5-Me-dC)
- 2-Amino-deoxyadenosine (2-Amino-dA)
BMN quenchers from biomers.net
In addition to this wide range of available quenchers, biomers.net also offers excellent alternatives.
Our biomers.net quencher set nearly covers the complete wavelength range of visible light:
BMN-Q460 (400-530 nm), BMN-Q535 (480-580 nm), BMN-Q590 (550-650 nm), BMN-Q620 (480-720 nm) and BMN-Q650 (550-720 nm)
Early Bird Discount
Between 6:00 and 9:30 am you‘ll get a special discount of
5 % on all your orders
!
Literature Highlights
Protocols, interesting literature and further information around the topic of oligonucleotides.

- Smart-Seq for transkriptome analysis (Picelli et al., 2014)
- Mediator Probe PCR (Faltin et al., 2012)
- MiL-FISH: Multi-labelled oligonucleotides (Schimak et al., 2015)
DNA oligos
- Unmodified oligos
- short and extra long oligos
- XXL DNA (10-500 mg)
- Sequence modifications
- Wobbles
RNA oligos
- unmodified RNA
up to 120 bases

- RNA oligo annealing
- XL and XXL RNA (5-50 mg)
- RNA modifications
- 2´-modified RNA
qPCR Probes
- Dual-Labelled Oligos
- Double Quenched Probes
- Molecular Beacons
- Scorpions
- FRET Probes
- PCR Blocker
PNA oligos
- Peptide nucleic acid oligomers (PNA)
- 6-25 bases
- various modifications possible
- extreme stability
FISH Probes
- Fluorescence probes
mono-, dope-, tetraProbes
- multiProbes
- HRP probes
- OligoPool 48 for smFISH
5-EdU -
Click modification
Alternative coupling strategy for multi-labelled oligos using the click bases 5-Ethynyl-dU,
5-Octynyl-dC and 5-Octynyl-dU

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