2´-O-Methyl-RNA for only 6,00 €/5.40£ per base (Scale S)
It has recently become possible to order RNA that are composed entirely of 2´-O-Methyl-RNA nucleotides, directly and comfortable online.
To do this, choose the type of nucleic acid in our online order form and order easily and conveniently
Full-2'-OMe-RNA nucleotides at low price.
The HPLC purification of the RNA oligos is included.
For further information please contact our customer support service at any time.
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This RNA has modifications at the 2'-position of ribose. biomers.net offers here a selection of different modifications:
If an oxygen is linked at 2´-carbon of the sugar, by definition it is a ribose. This does not mean that this ribose may bear the base thymine (instead of uracil)
Antisense oligonucleotides having a modification at the 2'-hydroxyl group (2´-methyl), often show an increased stability to enzymatic degradation. This also facilitates an improved distribution of the oligos in the cell, as well as improved pharmacokinetics of the antisense oligos can be derived1. Furthermore, it was observed that 2'-modified oligonucleotides (2´-O-methyl, 2´-O-propyl, 2´-O-fluoro) bind with greater affinity to complementary RNA2.
Please contact the biomers.net customer support for availability and delivery times.
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1. Pharmacokinetic Properties of 2´-O-(2-Methoxyethyl)-Modified Oligonucleotide Analogs in Rats. Geary RS, Watanabe TA, Truong L, Freier S, Lesnik EA, Sioufi NB, Samor H, Manoharan M, Levin AA; The Journal of Pharmacology and experimental Therapeutics (2001), Vol. 296, No. 3; JPET 296:890–897.
2. Evaluation of 2´-Modified Oligonucleotides Containing 2’-Deoxy Gaps as Antisense Inhibitors of Gene Expression. Monia BP, Lesnik EA, Gonzalez C, Lima WF, McGee D, Guinosso CJ, Kawasaki AM, Cook PD, Freier SM; The Journal of Biological Chemistry (1993), Inc. Val. 268, No. 19, pp. 14514-14522.