> Lipophile Modifikationen
Palmitate (5' modification)

Lit:
Thazha P Prakash, Adam E Mullick, Richard G Lee, Jinghua Yu, Steve T Yeh, Audrey Low, Alfred E Chappell, Michael E Østergaard, Sue Murray, Hans J Gaus, Eric E Swayze, Punit P Seth, Fatty acid conjugation enhances potency of antisense oligonucleotides in muscle, Nucleic Acids Research, Volume 47, Issue 12, 09 July 2019, Pages 6029–6044, https://doi.org/10.1093/nar/gkz354

Michael E Østergaard, Michaela Jackson, Audrey Low, Alfred E. Chappell, Richard G. Lee, Rachel Q Peralta, Jinghua Yu, Garth A Kinberger, Amy Dan, Rick Carty, Michael Tanowitz, Patrick Anderson, Tae-Won Kim, Linda Fradkin, Adam E Mullick, Sue Murray, Frank Rigo, Thazha P Prakash, C Frank Bennett, Eric E Swayze, Hans J Gaus, Punit P Seth, Conjugation of hydrophobic moieties enhances potency of antisense oligonucleotides in the muscle of rodents and non-human primates, Nucleic Acids Research, Volume 47, Issue 12, 09 July 2019, Pages 6045–6058, https://doi.org/10.1093/nar/gkz360
Palmitate 5' modification: 5'-Palmitate
5'-Palmitate