The tocopherol derivative Trolox also belongs to the vitamin E group. In comparison to tocopherol, Trolox is more hydrophilic and further shows strong antioxidant properties. Due to the improved intercellular effect and cellular uptake, new opportunities for oligo conjugates with these lipophilic modifications arise in the field of antisense oligonucleotides.
Furthermore, in combination with a fluorescent dye, Trolox is able to "stabilise" the dye and protect it against fading.