Reactive linkers: Aldehyde-Hydrazide
An efficient way to link oligos to other biomolecules is the hydrazide-aldehyde coupling. Aldehydes represent highly reacted carbonyl compounds that can react with hydrazides under neutral or slightly acidic conditions to form stable hydrazone conjugates in a fast and efficient way. Thus, a conjugation of oligonucleotides to other (bio)molecules can be achieved easily under physiological conditions.


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Enzymatic coupling
Protein tags such as SNAP or CLIP tag as well as HaloTag® but also the sortase-mediated linking reaction are used in various applications:

- detection
- localisation
- protein-protein interactions
- labelling, multiplex labelling (e.g. SNAP / CLIP tag)
- enzymatic coupling of different proteins or other biomolecules

Redox-active reporter molecules
Oligonucleotide-based biosensors (E-sensors) for
electrochemical detection can be labelled with
- NEW: Nile Blue
- Methylene blue
- Ferrocene
- Anthraquinone
- Viologen
- Atto MB2
Carbohydrate oligonucleotide conjugates
Carbohydrate oligo conjugates play an important role in improving uptake and cell availability of siRNA and antisense oligonucleotides.

Various carbohydrates (sugars) are available for oligo coupling:
- N-Acetylgalactosamine (GalNAc)
- ß-Cyclodextrin
- Glucopyranose
smiFISH
smiFISH - single molecule inexpensive fluorescence in situ hybridisation

A set consisting of short, target-binding, unlabelled oligo probes (OligoPool) and a double-labelled secondary probe allows extremely sensitive and specific in situ RNA detection.



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Literature Highlights
Protocols, interesting literature and further information around the topic of oligonucleotides.

- Smart-Seq for transkriptome analysis (Picelli et al., 2014)
- Mediator Probe PCR (Faltin et al., 2012)
- MiL-FISH: Multi-labelled oligonucleotides (Schimak et al., 2015)
DNA oligos
- Unmodified oligos
- short and extra long oligos
- XXL DNA (10-500 mg)
- Sequence modifications
- Wobbles
RNA oligos
- unmodified RNA
up to 120 bases

- RNA oligo annealing
- XL and XXL RNA (5-50 mg)
- RNA modifications
- 2´-modified RNA
qPCR Probes
- Dual-Labelled Oligos
- Double Quenched Probes
- MGB Probes
- Molecular Beacons
- Scorpions
- FRET Probes
PNA oligos
- Peptide nucleic acid oligomers (PNA)
- 6-25 bases
- various modifications possible
- extreme stability
FISH Probes
- Fluorescence probes
mono-, dope-, tetraProbes
- multiProbes
- HRP probes
- smiFISH Oligo Pools
Catalog Products
- Oligo products (Random Hexamer, Oligo dT20, Universal Reporter, RNase Substrate, etc)
- qPCR Mastermix
- Chemicals for oligonucleotide synthesis